After the Doctor earthed it in San Martino, it passed into the soil and survived as a biological entity, attaching itself to the chromosomes of the people of San Martino and being transferred from generation to generation it is thus able to control the descendents of the people of San Martino. It can draw on the power of belief generated by astrology. It refers to the Doctor as the Chaos Bringer. Specific attempts mentioned here include those involving the Sacred Mountain of Xi’an ( The Eleventh Tiger), the Orphans of the Future ( Buried Secrets, Snow Blind, Fatal Consequences, Dreamland), and the “Mandrake nightclub stuff” (The Doctor Who Magazine comic strip The Mark of Mandragora). The Mandragora Helix notes that it has made other attempts to invade Earth since 1492, but the alignments have never been perfect, so it has never been able to fully transmit itself to Earth. It is able to influence the Doctor’s psychic paper, making it display misleading messages for him. The Mandragora Helix escaped from the Dark Times and made its home in a Nebula. Continuity: The Masque of Mandragora is dated to 1492.
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